Certain medicines including Cialis should not be used with certain types of food since interactions may occur.
Coadministration of Cialis with grapefruit juice is likely to increase the plasma concentrations of Tadalafil, (AUC of Tadalafil). There is no clinically proven data on grapefruit juice and Cialis interactions, still patients should not use grapefruit products with Cialis until they discuss it with a doctor. The supposed interaction mechanism is blocking of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. It is known that Tadalafil isprimarily metabolized by CYP450 3A4.
So men taking Tadalafil should be instructed about the usage of grapefruit products with Cialis.
Coadministration of Cialis with grapefruit juice is likely to increase the plasma concentrations of Tadalafil, (AUC of Tadalafil). There is no clinically proven data on grapefruit juice and Cialis interactions, still patients should not use grapefruit products with Cialis until they discuss it with a doctor. The supposed interaction mechanism is blocking of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. It is known that Tadalafil isprimarily metabolized by CYP450 3A4.
So men taking Tadalafil should be instructed about the usage of grapefruit products with Cialis.